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Non-receptor type 22 protein tyrosine phosphatase (PTPN22) polyclonal antibody
 
Cat. No. Format Size Price
PAB-10786 Purified 100 µg 275 Euro
Animal ID: 
RB0381-0382 
 
Host: 
Rabbit 
 
Reactivity: 
human 
 
Buffers: 
Purified rabbit polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS. 
 
Storage: 
Maintain refrigerated at 2-8ºC for up to 6 months. For long term storage store at -20ºC. Avoid repeated freeze-thaw cycles. 
 
Application: 
Tested by peptide-specific ELISA (1:1,000). 
 
Immunogen:
KLH conjugated synthetic peptide comprised of amino acids 767 - 781 [CPPNKPAESVQSNNS] of the human non-receptor type 22 protein tyrosine phosphatase (PTPN22) protein. 
Accession number:
NM_015967 
Description:
Following activation of T cells, phosphorylation of tyrosine residues occurs through a complex signaling process involving protein tyrosine kinases, phosphatases, and a variety of adapter molecules including Grb2. The non-receptor type 22 protein tyrosine phosphatase (PTPN22) is an enzyme which associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. PTPN22 contains three SH3 domains and a PTB domain binding motif, and it is primarily expressed in lymphoid tissues.
Alternative Name(s):
LYP, Lyp, Lyp1, Lyp2, protein tyrosine phosphatase homolog, lymphoid-specific protein tyrosine phosphatase 
References:
 
  1. Chien W, Tidow N, Williamson EA, Shih LY, Krug U, Kettenbach A, Fermin AC, Roifman CM, Koeffler HP: Characterization of a myeloid tyrosine phosphatase, Lyp, and its role in the Bcr-Abl signal transduction pathway. J. Biol. Chem. 278(30): 27413-27420 (2003).
  2. Hill RJ, Zozulya S, Lu YL, Ward K, Gishizky M, Jallal B: The lymphoid protein tyrosine phosphatase Lyp interacts with the adaptor molecule Grb2 and functions as a negative regulator of T-cell activation. Exp. Hematol. 30(3): 237-244 (2002).
  3. Cohen S, Dadi H, Shaoul E, Sharfe N, Roifman CM: Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp. Blood 93(6): 2013-2024 (1999).

 

For Research Use Only. Not for Diagnostic or Therapeutic Use.
 

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