GENTAUR EUROPE  +32 1658 9045 +32 1650 9045BELGIUM1 tel +32 2 732 5688 fax +32 2 732 4414 [email protected] Av. de l' Armée 68 B-1040 Brussels France tel 01 43 25 01 50 fax 01 43 25 01 60 9, rue Lagrange 75005 Paris Italy tel 02 36 00 65 93 fax +32 16 50 90 45 20135 Milano Germany tel +32 16 58 90 45 fax +32 16 50 90 45 Forckenbeckstraße 6 D-52074 Aachen Japan tel +81 78 386 0860 fax +81 78 306 0296 Minaatojimaminami-manchi Chuo-ku, Kobe 065-0047  |
| p53 Tumor
Suppressor Gene Product (DO1) Clone: DO1 Isotype: IgG1 p53 (53 kDa) Oncoprotein - the SIGNET p53
monoclonal antibody, clone D01, detects a denaturation resistant epitope
in the human p53 protein. The p53 protein is present in minute amounts
in normal cells and tissues, but high concentrations of the protein
occur in a large number of tumors and tumor cell lines, enabling it to
be detected by immunohistochemistry (nuclear staining). The increased
concentration in tumor cells may be caused by complexing with other
proteins, or by mutation of the p53 protein. The gene for p53 is located
on chromosome 17p, a frequent site of allele loss in many tumors,
including lung, colon, breast, ovarian, testicular, bladder, brain,
melanoma, certain types of leukemias, and neurofibrosarcoma. Expression
of the p53 oncoprotein has been shown to correlate with poor prognosis
in breast cancer.
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| Catalog # | Format | Quantity | Price |
| 518-01 | Concentrate | 1ml | 359.10 |
| 518-16 | Level 1 predilute | 6ml | 359.10 |
| 518-26 | Level 2 predilute | 6ml | 324.00 |
