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Item Rabbit Anti-Emi1 Polyclonal Antibody
Antigen Emi1
Catalog Number 24243
Quantity 100 ul

 Complementary infromation

 

Human protein: Q9UKT4 - F-box only protein 5 (Early mitotic inhibitor 1)

Length: 447 aa, molecular weight: 50146 Da, CRC64 checksum: 196FBC2578F92120

     MSRRPCSCAL RPPRCSCSAS PSAVTAAGRP RPSDSCKEES STLSVKMKCD FNCNHVHSGL        60
     KLVKPDDIGR LVSYTPAYLE GSCKDCIKDY ERLSCIGSPI VSPRIVQLET ESKRLHNKEN       120
     QHVQQTLNST NEIEALETSR LYEDSGYSSF SLQSGLSEHE EGSLLEENFG DSLQSCLLQI       180
     QSPDQYPNKN LLPVLHFEKV VCSTLKKNAK RNPKVDREML KEIIARGNFR LQNIIGRKMG       240
     LECVDILSEL FRRGLRHVLA TILAQLSDMD LINVSKVSTT WKKILEDDKG AFQLYSKAIQ       300
     RVTENNNKFS PHASTREYVM FRTPLASVQK SAAQTSLKKD AQTKLSNQGD QKGSTYSRHN       360
     EFSEVAKTLK KNESLKACIR CNSPAKYDCY LQRATCKREG CGFDYCTKCL CNYHTTKDCS       420
     DGKLLKASCK IGPLPGTKKS KKNLRRL                                           447
//

 

 

 

 

 

 

General information

Entry name

FBX5 HUMAN

Accession number

Q9UKT4, Q8WV29, Q9UGC8

Created

Rel. 41, 28-FEB-2003

Sequence update

Rel. 41, 28-FEB-2003

Annotation update

Rel. 42, 10-OCT-2003

Description and origin of the Protein

Description

F-box only protein 5 (Early mitotic inhibitor 1).

Gene name(s)

FBXO5 OR FBX5 OR EMI1.

Organism source

Homo sapiens (Human).

Taxonomy

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.

NCBI TaxID

9606

References

[1]

Cenciarelli,C., Chiaur,D.S., Guardavaccaro,D., Parks,W., Vidal,M., Pagano,M.,
Identification of a family of human F-box proteins.

(1999) Curr. Biol. 9:1177-1179

Position

SEQUENCE FROM N.A.

Medline

20003060

PubMed

10531035

[2]

Hsu,J.Y., Reimann,J.D.R., Sorensen,C.S., Lukas,J., Jackson,P.K.,
The E2F-dependent accumulation of EMI1 regulates S phase entry by inhibiting APCCdh1.Submitted FEB-2002 to the EMBL GenBank DDBJ databases

Position

SEQUENCE FROM N.A.

[3]

Phillimore,B., Submitted DEC-1999 to the EMBL GenBank DDBJ databases

Position

SEQUENCE FROM N.A.

[4]

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S.N., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J.M., Marra,M.A.,
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.

(2002) Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903

Position

SEQUENCE FROM N.A.

Comments

TISSUE=Placenta;

Medline

22388257

PubMed

12477932

Comments

FUNCTION

Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.

SUBUNIT

Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity).

SIMILARITY

Contains 1 F-box domain.

 

 

Database cross-references

EMBL

AF129535; AAF04469.1; -.

AY079515; AAL86610.1; -.

AL080276; CAB65993.1; -.

BC018905; AAH18905.1; -.

Genew

HGNC:13584; FBXO5.

MIM

606013; -.

GO

GO:0004840; F:ubiquitin conjugating enzyme activity; TAS.

GO:0004842; F:ubiquitin-protein ligase activity; TAS.

GO:0006508; P:proteolysis and peptidolysis; TAS.

InterPro

IPR001810; F-box.

Pfam

PF00646; F-box; 1.

PROSITE

PS50181; FBOX; FALSE_NEG.

Keywords

Ubl conjugation pathway;

Features

Key

Begin

End

Length

Description

DOMAIN

250

296

47

F-box.

CONFLICT

107

107

1

Q -> E (in Ref. 4).

CONFLICT

304

329

26

Missing (in Ref. 3).

HOMOLOGENE ENTRY


H.sapiens -FBXO5

F-box only protein 5
UniGene | LocusLink | MIM | MapViewer | NM_012177.2

POSSIBLE HOMOLOGOUS GENES


M.musculus -Fbxo5

F-box only protein 5
UniGene | LocusLink | MGI | MapViewer | NM_025995.1


R.norvegicus -LOC292263

similar to Fbxo5 protein
UniGene | LocusLink | MapViewer | XM_214756.2


S.scrofa -Ssc.24858

Transcribed sequence with moderate similarity to protein refNP_036309.1 (H.sapiens) F-box only protein 5; F-box protein Fbx5; homolog of xenopus EMI1 [Homo sapiens]
UniGene | CK466339.1 | BG733555.1 | CK468447.1


B.taurus -Bt.986

Transcribed sequences
UniGene | CB435835.1 | CB435564.1

 

 

  GeneReport for:
AF129535
 
FBXO5
F-box only protein 5
UniGene, LocusLink, OMIM, GenAtlas, GeneCard, Ensembl, MapView, Genome Browser
Aliases
  • EMI1, XENOPUS, HOMOLOG OF
  • F-box protein Fbx5
Chromosomal Location
Chromosome/Cytoband
6q25-q26
LocusLink Information
Locus Link Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex.
Annotations
Gene Ontologies

Ontology

Annotation

Evidence Source
Molecular Function Ubiquitin conjugating enzyme activity TAS GOA
Ubiquitin-protein ligase activity TAS GOA
Biological Process Proteolysis and peptidolysis TAS GOA
UniGene & EST Expression Information
UniGene Cluster
Hs.272027 from Build No. 166 ,   Released on 2004-01-17
Normalized expression distribution for tissue type
Top ten [of 38]

[Help]
Tissue Normalized
Expression (%)
Cluster Clones :
Tissue clones
juvenile granulosa tumor: 8.69 1:2247
malignant melanoma, metastatic to lymph node: 7.26 1:2691
metastatic prostate bone lesion: 6.77 1:2884
lung carcinoma: 5.71 1:3424
germinal center B cell: 4.73 9:37172
kidney tumor: 4.01 1:4869
squamous cell carcinoma: 3.78 2:10343
sciatic nerve: 3.71 1:5269
ovarian tumor: 3.71 2:10544
from acute myelogenous leukemia: 3.56 1:5485
SAGE (NCBI)
Go to Gene-to-tag Mapping at NCBI
Upstream Genomic Sequence
TRASER
Upstream genomic sequence for F-box only protein 5
Representative mRNA Sequences
UniGene
NM_012177
LocusLink RefSeq
Accession Description
NM_012177 NA
Alias PubMed Search
PubMed

 

   
name begin end E-value
low complexity 11 23 -
low complexity 151 167 -
Pfam:F-box 245 296 1.20e-02

   

ACTIVATE: SOSUI analysis
This amino acid sequence is of a SOLUBLE PROTEIN.

   
 	 73.9 %: mitochondrial
	 17.4 %: nuclear
	  4.3 %: cytoskeletal
	  4.3 %: cytoplasmic

 
Activate MapView for: Q9UKT4


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Last modified: 05/19/16