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MRP5 (M5I-1)
Clone: M5I-1

MRP5 is closely related to MRP4, both lacking the first five membrane-spanning regions. MRP5 is a GS-X multi-specific organic anion pump (nucleotide analogs). MRP 5 may tansport DNP-GS and may be inhibited by certain inhibitors of organic anion trasport (sulfinpyrazone). MRP5 may also transport organic anions with the anionic moiety of phosphate/phosphonate group, a function which provides the ability to resist against anticancer drugs 6-MP and thioguanine as well as the anti-HIV drug PMEA. Signet's MDR rat monoclonal M5I-1 reacts with an internal epitope of the membrane transport protein of MRP5 (190-200kD). The immunogen is a bacterial fusion protein of MRP5 containing the segment of 82-168 AA. M5I-1 has been worked up in Western blot, ICC and IHC (frozen tissue only) protocols.
Master Cat. No. 8810 Cat. No. 8810-01 Clone: M5I-1

 

Catalog # Format Quantity Price
8810-01   Concentrate   1ml   463.50  

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Last modified: 05/19/16