The Signet CD50 (186-2G9) antibody reacts with the single chain 120kDa polypeptide cellular adhesion molecule (CD50 antigen ICAM-3). The protein is heavily glycosylated and resistant to treatment with phosphatidylinosital phospholipase C and therefore probably not Pl-anchored to the membrane. CD50 antigen is constitutively expressed at high levels on leukocytes, including epidermal, dentritic Langerhans cells and is released from activated lymphocytes and neutrophils. It is detected on blood vessel walls within some lymphomas and a soluble form is delectable in blood. The CD50 molecule mediates adhesion between leukocytes and appears to be important in the initial interactions between T cells and dentritic cells leading to T cell activation. In general, CD50 antigen expression is restricted to haematological neoplasms with a tendency to be lost in high grade lymphomas and Reed-Sternberg cells. Endothelial cells from tumor-associated neovascularisation in both lymphoid and solid tumors also express CD 50 antigen.
Master Cat. No. 648 Cat. No. 648 Clone: 186-2G9