UCHL1 was officially designated a CD45RO at the Fourth International Workshop on Human Leukocyte Differentiation Antigens - 1989. The Leukocyte Common Antigen, LCA, family of antigens comprises at least five high molecular weight glycoproteins (MW 180, 190, 205, 220 kD). These glycoproteins are found on the cell surface of the majority of human leukocytes. The SIGNET UCHL1 Monoclonal anti-CD45RO is specific for the 180 kD low molecular weight isoform of CD45 or Leukocyte Common Antigen (LCA/CD45). This antibody and antibodies to the high molecular weight form of CD45 (CD45R) seem to define complementary, largely non-overlapping populations in resting peripheral T cells. This demonstrates the heterogeneity within the CD4 and CD8 subsets. UCHL1 labels most thymocytes, a subpopulation of resting T cells within both the CD4 and CD8 subsets, mature activated T cells, granulocytes and monocytes. Normal B cells or NK cells are consistently negative. Weak cytoplasmic staining is seen in cases of centroblastic and immunoblastic lymphoma. The antibody also recognizes approximately 50% of Human CD4 positive and 35% of CD8 positive T cells in peripheral blood, as well as functionally distinct subset of human helper-inducer T cells. Available in:
Master Cat. No. 331 Cat. No. 331 Clone: UCHL1