The Signet CD23 (BU38) monoclonal antibody recognizes the B cell differentiation antigen CD23, a 45-50kDa type II trans-membrane glycoprotein. The antigen acts as a low affinity IgE receptor (FcER2) and is expressed at variable degrees on follicular mantle B cells and also occasionally in the splenic marginal zones or in germinal centers. The CD23 antibody gives a characteristic-binding pattern with follicular dentritic cells but the antigen is absent on plasma cells and B cell progenitors. Expression of CD23 antigen is greatest in activated B-lymphocytes. Cleavage of the membrane bound form releases a series of soluble fragments, which still bind the IgG except for the 12 kDa moiety. This antibody also reacts with B cells in chronic lymphocytic leukemia and some cases of centroblastic/centrocytic lymphoma.
Master Cat. No. 636 Cat. No. 636 Clone: BU 38