GENTAUR EUROPE  +32 1658 9045 +32 1650 9045BELGIUM1 tel +32 2 732 5688 fax +32 2 732 4414 [email protected] Av. de l' Armée 68 B-1040 Brussels France tel 01 43 25 01 50 fax 01 43 25 01 60 9, rue Lagrange 75005 Paris Italy tel 02 36 00 65 93 fax +32 16 50 90 45 20135 Milano Germany tel +32 16 58 90 45 fax +32 16 50 90 45 Forckenbeckstraße 6 D-52074 Aachen Japan tel +81 78 386 0860 fax +81 78 306 0296 Minaatojimaminami-manchi Chuo-ku, Kobe 065-0047  |
| C219 MDR
Multidrug Resistance Clone: C219 C219 recognizes an internal, highly
conserved amino acid sequence (VQEALD & VQAALD) found in both Mdr1 and
Mdr3 isoforms of P-glycoprotein. The specific binding of the clone C219
was stronger in epitope sequence VQAALD (N-Terminal fragment) than the
epitope sequence VQEALD (C-terminal fragmant) (Geoges E., et al.,
(1990). C219 is not species-specific. Immunohistochemical analysis of
rat and human skeletal and cardiac muscle, as well as immunoblots of
cardiac muscle tissue, have shown that C219 cross-reacts with a Mr
200,000 protein which migrates in the same position as myosin. Also, in
a recent publication, Liu BL., et al., has reported that the C219 mAB
cross-reacts with the c-erbB2 protein (p185 c-erbB2). Care should be
taken in the interpretation of true positive P-glycoprotein expression
when using myosin-containing tissues or tissues known to have p185
c-erbB2 expression. |
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| Catalog # | Format | Quantity | Price |
| 8710-01 | Concentrate | 1ml | 437.40 |
