Animal ID:
RB0379-0380
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Host:
Rabbit
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Reactivity:
human
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Buffers:
Purified rabbit polyclonal antibody supplied in PBS with 0.09% (W/V)
sodium azide. This antibody is purified through a protein G column and
eluted out with both high and low pH buffers and neutralized immediately
after elution then followed by dialysis against PBS.
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Storage:
Maintain refrigerated at 2-8ºC for up to 6 months. For long term storage
store at -20ºC. Avoid repeated freeze-thaw cycles.
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Application:
Tested by peptide-specific ELISA (1:1,000).
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Immunogen:
KLH conjugated synthetic peptide comprised of amino acids 311 - 325
[CIPEKNHTLQADSYS] of the human non-receptor type 22 protein tyrosine
phosphatase (PTPN22) protein. |
Accession number:
NM_015967 |
Description:
Following activation of T cells, phosphorylation of tyrosine residues
occurs through a complex signaling process involving protein tyrosine
kinases, phosphatases, and a variety of adapter molecules including
Grb2. The
non-receptor type 22 protein tyrosine phosphatase (PTPN22) is an
enzyme which associates with the molecular adapter protein CBL and may
be involved in regulating CBL function in the T-cell receptor signaling
pathway. PTPN22 contains three SH3 domains and a PTB domain binding
motif, and it is primarily expressed in lymphoid tissues. |
Alternative Name(s):
LYP, Lyp, Lyp1, Lyp2, protein tyrosine phosphatase homolog,
lymphoid-specific protein tyrosine phosphatase |
References:
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Chien W, Tidow N, Williamson EA, Shih LY, Krug U, Kettenbach A, Fermin
AC, Roifman CM, Koeffler HP: Characterization of a myeloid
tyrosine phosphatase, Lyp, and its role in the Bcr-Abl signal
transduction pathway. J. Biol. Chem. 278(30): 27413-27420
(2003).
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Hill RJ, Zozulya S, Lu YL, Ward K, Gishizky M, Jallal B: The
lymphoid protein tyrosine phosphatase Lyp interacts with the adaptor
molecule Grb2 and functions as a negative regulator of T-cell
activation. Exp. Hematol. 30(3): 237-244 (2002).
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Cohen S, Dadi H, Shaoul E, Sharfe N, Roifman CM: Cloning and
characterization of a lymphoid-specific, inducible human protein
tyrosine phosphatase, Lyp. Blood 93(6): 2013-2024 (1999).
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For Research Use Only. Not for Diagnostic or Therapeutic Use.
Purchase does not include or carry any right to resell or transfer
this product either as a stand-alone product or as a component of
another product. Any use of this product other than the permitted use
without the express written authorization of Orbigen, Inc. is strictly
prohibited |
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+32 1658 9045
+32 1650 9045
