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Anti-Alivin 1 Polyclonal Antibody
Catalog Number: 25-24357 Price: 282 Euro / 333 USD
Lot Number: R5711
Quantity: 100 mg in 100 ml (1 mg/ml) in PBS containing 0.02% sodium azide.
Description: A novel primary response gene, Alivin 1 (ali1), is an activity-dependent gene and promotes survival of neurons. Sequence analyses reveal that rat, mouse, and human Ali1 proteins contain seven leucine-rich repeats, one IgC2-like loop and a transmembrane domain, and display homology to Kek and Trk families. Results suggest that expression of ali1 promotes depolarization-dependent survival of the granule neuron. Mouse ali1 was mapped to a locus approximately 55.3 cM from the centromere on chromosome 15 that is syntenic to positional candidate loci for familial Alzheimer's disease type 5 and Parkinson's disease 8 on human chromosome 12.
Host Species: Rabbit
Specificity: Reacts with residues 449-464 [TGDASADDRKAGKRVV] of mouse and rat Alivin 1. 81% sequence identity to human. Detects bands of 63 ands 66 kDa in brain with the majority of the immunoreactivity in the nuclear fraction.
Application: Western blot – Use at 1:500 dilution. However, the investigator should determine the optimal dilution for a specific application such as immunohistochemistry.
Format: Affinity purified IgG
Storage: Maintain at +2-8°C for 3 months or at -20°C for longer periods. Stable for 1 year. Avoid repeated freeze-thaw cycles.
Reference: Ono,T. et. al. J. Neurosci. 23 (13), 5887-5896 (2003).
