GENTAUR EUROPE  +32 1658 9045 +32 1650 9045BELGIUM1 tel +32 2 732 5688 fax +32 2 732 4414 [email protected] Av. de l' Armée 68 B-1040 Brussels France tel 01 43 25 01 50 fax 01 43 25 01 60 9, rue Lagrange 75005 Paris Italy tel 02 36 00 65 93 fax +32 16 50 90 45 20135 Milano Germany tel +32 16 58 90 45 fax +32 16 50 90 45 Forckenbeckstraße 6 D-52074 Aachen Japan tel +81 78 386 0860 fax +81 78 306 0296 Minaatojimaminami-manchi Chuo-ku, Kobe 065-0047  |
| URO-1
Renal Panel Clone: J143 Mr 140,000/120,000/30,000 glycoprotein.The
SIGNET J143 monoclonal antibody recognizes the alpha 3 subunit of VLA-3
(ECMR I - extracellular matrix receptor I), which has been shown to be
related to the chicken fibronectin/laminin receptor. VLA proteins are
part of the integrin family of cell adhesion molecules, and the
distribution of VLA-3 in cells and tissues suggests a possible
relationship with cellular adhesion. J143 reacts predominantly with
adherent cell types and is absent from cells growing in suspension, e.g.
leukemia, lymphoma, lymphoblastoid, or other hematopoietic cell lines.
In tissues, the URO-1 antigen is expressed by glomeruli, the basal layer
of transitional epithelium and skin, and the basement membrane of
glands. All bladder tumors express URO-1, as do most kidney tumors and
other epithelial tumors (e.g. colon, ovary, lung and breast).
Astrocytoma, melanoma, sarcoma, and lymphoma specimens are negative.
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| Catalog # | Format | Quantity | Price |
| 8010-01 | Concentrate | 1ml | 257.40 |
