The antibody detects a high molecular weight (>200 kD) glycoprotein antigenic determinant known as CA 125. It reacts with an antigen common to most non-mucinous epithelial ovarian carcinomas. It is positive in serous and endometrioid adenocarcinomas, in Krukenberg's tumor and uterine myoma. Mucinous tumors (benign, borderline, malignant) and normal ovarian epithelium are negative. The CA 125 antigen is also detectable on the apical surface of normal epithelial cells of the pleura, pericardium, peritoneum fallopian tube, endometrium and endocervix. Normal breast, skin, liver, spleen, and kidney are negative.
Master Cat. No. 617 Cat. No. 617 Clone: OC 125 Isotype: IgG1